Naproxen Solution

Specifications / Handling

More Information
Product Details
Synonyms	(S)-Naproxen; (+)-Naproxen; (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid; Equiproxen; Laraflex
Product Type	Chemical
Properties
Formula	C₁₄H₁₄O₃
MW	230.26
CAS	22204-53-1
RTECS	UF5275000
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥98% (HPLC)
Appearance	Liquid. 1mg/ml in methanol.
Solubility	Soluble in aqueous buffers.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	CMWTZPSULFXXJA-VIFPVBQESA-N
Smiles	C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Naproxen is a potent, non-steroidal, non-selective anti-inflammatory cyclooxygenase (COX-1 and COX-2) inhibitor. Inhibits COX-1 expression in HUVECS at a concentration of 5µg/ml. This COX inhibitor is indicated for the treatment of pain, fever, inflammation and stiffness. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).

Product References

(1) W.F. Kean, et al.; J. Pharm. Sci. 78, 324 (1989) | (2) T. Zyglewska, et al.; Biochim. Biophys. Acta 1131, 78 (1992) | (3) J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) | (4) O. Laneuville, et al.; J. Pharmacol. Exp. Ther. 271, 927 (1994) | (5) N.M. Davies & K.E. Anderson; Clin. Pharmacokinet. 32, 268 (1997) | (6) N. Monck; IDrugs 6, 593 (2003) | (7) T. Takeda, et al.; J. Phys. Chem. B. 114, 15394 (2010) | (8) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010)

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