(S)-5-Chloronaproxen

Specifications / Handling

More Information
Product Details
Synonyms	Naproxen Impurity B; (αS)-5-Chloro-6-methoxy-α-methyl-2-naphthaleneacetic acid; (2S)-2-(5-Chloro-6-methoxy-2-naphthyl)propionic acid
Product Type	Chemical
Properties
Formula	C₁₄H₁₃ClO₃
MW	264.7
CAS	89617-86-7
Source/Host Chemicals	Synthetic
Purity Chemicals	≥98% (NMR)
Appearance	White powder.
Solubility	Soluble in chloroform.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	RVVAYDHIVLCPBC-QMMMGPOBSA-N
Smiles	ClC1=C(C=CC([C@@H](C(O)=O)C)=C2)C2=CC=C1OC
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

(S)-5-Chloronaproxen (Naproxen Impurity B) is a chlorinated metabolite (most probably through reaction with water) from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a secondary analytical reference standard or as an organic building block and intermediate for synthesis, especially targeted chlorination.

Product References

(1) E.M. Santangelo, et al.; Eur. J. Org. Chem. 2008, 5915 (2008) | (2) K. Solakyildirim, et al.; Magn. Reson. Chem. 52, 310 (2014)

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