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Chemodex
(+)-Naproxen methyl ester
84
CHF
CHF 84.00
In stock
CDX-N0557-M05050 mgCHF 84.00
| Product Details | |
|---|---|
| Synonyms | (S)-Naproxen methyl ester; NME; Naproxen Impurity E (PhEur); (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester; Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoat |
| Product Type | Chemical |
| Properties | |
| Formula | C15H16O3 |
| MW | 244.29 |
| CAS | 26159-35-3 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder or crystals. |
| Solubility | Soluble in chloroform, methanol or DCM. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ZFYFBPCRUQZGJE-UHFFFAOYSA-N |
| Smiles | C(C(OC)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The metabolite Naproxen methyl ester (Naproxen Impurity E) is a degradation product from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a control esterase substrate, as a working standard or secondary analytical reference standard or as an organic building block and intermediate for synthesis.
Product References
(1) M. Najlah, et al.; Int. J. Pharm. 308, 175 (2006) | (2) H. Weber, et al.; Arch. Pharm. 327, 337 (1994) | (3) C.J. Welch, et al.; J. High Resol. Chromatogr. 20, 179 (1997) | (4) H. Weber, et al.; Pharma. Res. 18, 600 (2001) | (5) J. Krzek & M. Starek; J. Plan. Chromatogr. 17, 137 (2004) | (6) L. Steenkamp & D. Brady; Proc. Biochem. 43, 1419 (2008) | (7) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010) | (8) R.S. Reddy, et al.; TACL 6, 55 (2016) | (9) I. Cacciatore, et al.; Int. J. Mol. Sci. 17, 1035 (2016) | (10) K. Birgul, et al.; Eur. J. Med. Chem. 208, 112841 (2020)