Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
13-cis-4-Oxoretinoic acid
150
CHF
CHF 150.00
In stock
CDX-O0048-M0011 mgCHF 150.00
CDX-O0048-M0055 mgCHF 597.00
CDX-O0048-M02525 mgCHF 2'388.00
| Product Details | |
|---|---|
| Synonyms | 4-Oxoisotretinoin; Ro 22-6595 |
| Product Type | Chemical |
| Properties | |
| Formula | C20H26O3 |
| MW | 314.42 |
| CAS | 71748-58-8 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Dark yellow powder. |
| Solubility | Soluble in acetone, chloroform, ethanol (slightly) or ether. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | GGCUJPCCTQNTJF-FAOQNJJDSA-N |
| Smiles | C\C(\C=C\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C\C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Mayor active metabolites of 13-cis-retinoic acid (important drug in dermatology and treatment of neuroblastoma) with effects on gene transcription that regulate growth, differentiation and inflammation in normal and neoplastic skin cells. Shown to be as active as 13-cis-retinoic acid against neuroblastoma cell lines. Can be used as reference compound.
Product References
(1) F.M. Vane & C.J. Bugge; Drug Metab. Dispos. 9, 515 (1981) | (2) J.M. Baron, et al.; J. Invest. Derm. 125, 143 (2005) | (3) S.E. Rowbotham, et al.; DMD 38, 1211 (2010) | (4) P. Sonawane, et al.; Br. J. Pharmacol. 171, 5330 (2014)