13-cis-4-Oxoretinoic acid

CHF 140.00
In stock
CDX-O0048-M0011 mgCHF 140.00
CDX-O0048-M0055 mgCHF 561.00
CDX-O0048-M02525 mgCHF 2'246.00
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Product Details
Synonyms 4-Oxoisotretinoin; Ro 22-6595
Product Type Chemical
Properties
Formula C20H26O3
MW 314.42
CAS 71748-58-8
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (HPLC)
Appearance Dark yellow powder.
Solubility Soluble in acetone, chloroform, ethanol (slightly) or ether.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key GGCUJPCCTQNTJF-FAOQNJJDSA-N
Smiles C\C(\C=C\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C\C(O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Mayor active metabolites of 13-cis-retinoic acid (important drug in dermatology and treatment of neuroblastoma) with effects on gene transcription that regulate growth, differentiation and inflammation in normal and neoplastic skin cells. Shown to be as active as 13-cis-retinoic acid against neuroblastoma cell lines. Can be used as reference compound.

Product References

(1) F.M. Vane & C.J. Bugge; Drug Metab. Dispos. 9, 515 (1981) | (2) J.M. Baron, et al.; J. Invest. Derm. 125, 143 (2005) | (3) S.E. Rowbotham, et al.; DMD 38, 1211 (2010) | (4) P. Sonawane, et al.; Br. J. Pharmacol. 171, 5330 (2014)

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