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Chemodex
4-Methylumbelliferyl palmitate
95
CHF
CHF 95.00
In stock
CDX-P0038-M250250 mgCHF 95.00
CDX-P0038-G0011 gCHF 285.00
| Product Details | |
|---|---|
| Synonyms | 4-MUP; 4-MU Palmitate; 4-Methyl-2-oxo-2H-chromen-7-yl palmitate; Palmitic acid 4-methylumbelliferyl ester |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H38O4 |
| MW | 414.59 |
| CAS | 17695-48-6 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white crystalline powder. |
| Solubility | Soluble in DCM (10mg/ml), chloroform (20mg/ml) or DMF (10mg/m). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QKQVFFACWLFRRX-UHFFFAOYSA-N |
| Smiles | O=C1OC2=CC(OC(CCCCCCCCCCCCCCC)=O)=CC=C2C(C)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL). 4-MUP is cleaved by LAL (or by other acid lipases) to release the fluorescent moiety 4-MU. Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP. Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase. Spectral data: 4-MU fluorescence is pH-dependent. λex 320nm (pH 1.97-6.72) and 360nm (pH 7.12-10.3); λem 445-455nM (increasing as pH decreases).
Product References
(1) G.J. Guy & J. Butterworth; Clin. Chim. Acta 84, 361 (1978) | (2) S. Kelly & R. Bakhru-Kishore; Clin. Chim. Acta 97, 239 (1979) | (3) T.G. Warner, et al.; Am. J. Hum. Gen. 32, 869 (1980) | (4) T.G. Warner, et al.; J. Biol. Chem. 256, 2952 (1981) | (5) M.W. Baillargeon & S.G. McCarthy; Lipids 26, 831 (1991) | (6) J. Hamilton, et al.; Clin. Chim. Acta 413, 1207 (2012) | (7) H. Zhi, et al.; J. Spectrosc. 1, 147128 (2013) | (8) T. Dairaku, et al.; Mol. Gen. Metab. 111, 193 (2014)