CHF 129.00
In stock
CDX-P0063-M0055 mgCHF 129.00
CDX-P0063-M02525 mgCHF 516.00
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Product Details
Synonyms NCH 51; Cpd 51; S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate
Product Type Chemical
Formula C20H26N2O2S2
MW 390.56
CAS 848354-66-5
Source/Host Chemicals Synthetic.
Purity Chemicals ≥95% (HPLC)
Appearance White crystals.
Solubility Soluble in DMSO (25mg/ml).
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Non-hydroxamate HDAC inhibitor (HDACi) (IC50: 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively). Cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1μM). Also reactivates latent HIV-1 gene expression.

Product References

(1) T. Suzuki, et al.; J. Med. Chem. 48, 1019 (2005) | (2) T. Sanda, et al.; Leukemia 21, 2344 (2007) | (3) T. Suzuki, et al.; Bioorg. Med. Chem. Lett. 17, 1558 (2007) | (4) A.F. Victoriano, et al.; FEBS Lett. 585, 1103 (2011)

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