|Purity Chemicals||≥95% (HPLC)|
|Solubility||Soluble in DMSO.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).
(1) Z. Xia, et al.; J. Med. Chem. 52, 74 (2009) | (2) Y.-W. Lin, et al.; Blood 115, 824 (2010) | (3) Z. Beharry, et al.; PNAS 108, 528 (2011) | (4) B. Cen, et al.; Cancer Res. 73, 3402 (2013) | (5) B. Cen, et al.; Mol. Cell. Biol. 34, 2517 (2014) | (6) M. Hiasa, et al.; Leukemia 29, 207 (2015)