5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione

CHF 102.00
In stock
CDX-P0110-M0055 mgCHF 102.00
CDX-P0110-M01010 mgCHF 162.00
CDX-P0110-M05050 mgCHF 651.00
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Product Details
Synonyms (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione; SMI-16a
Product Type Chemical
Formula C13H13NO3S
MW 263.3
CAS 587852-28-6
Source/Host Chemicals Synthetic
Purity Chemicals ≥95% (HPLC)
Appearance Yellow powder.
Solubility Soluble in DMSO.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Smiles CCCOC1=CC=C(\C=C2/SC(=O)NC2=O)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).

Product References

(1) Z. Xia, et al.; J. Med. Chem. 52, 74 (2009) | (2) Y.-W. Lin, et al.; Blood 115, 824 (2010) | (3) Z. Beharry, et al.; PNAS 108, 528 (2011) | (4) B. Cen, et al.; Cancer Res. 73, 3402 (2013) | (5) B. Cen, et al.; Mol. Cell. Biol. 34, 2517 (2014) | (6) M. Hiasa, et al.; Leukemia 29, 207 (2015)

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