5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione

CHF 96.00
In stock
CDX-P0110-M0055 mgCHF 96.00
CDX-P0110-M01010 mgCHF 153.00
CDX-P0110-M05050 mgCHF 612.00
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Product Details
Synonyms (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione; SMI-16a
Product Type Chemical
Properties
Formula C13H13NO3S
MW 263.3
CAS 587852-28-6
Source/Host Chemicals Synthetic
Purity Chemicals ≥95% (HPLC)
Appearance Yellow powder.
Solubility Soluble in DMSO.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key GBWOSXZUTXXXQF-FLIBITNWSA-N
Smiles CCCOC1=CC=C(\C=C2/SC(=O)NC2=O)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).

Product References

(1) Z. Xia, et al.; J. Med. Chem. 52, 74 (2009) | (2) Y.-W. Lin, et al.; Blood 115, 824 (2010) | (3) Z. Beharry, et al.; PNAS 108, 528 (2011) | (4) B. Cen, et al.; Cancer Res. 73, 3402 (2013) | (5) B. Cen, et al.; Mol. Cell. Biol. 34, 2517 (2014) | (6) M. Hiasa, et al.; Leukemia 29, 207 (2015)

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