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Chemodex
Puerarin
177
CHF
CHF 177.00
In stock
CDX-P0250-M250250 mgCHF 177.00
| Product Details | |
|---|---|
| Synonyms | Kakonein; NPI 031G; 8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Product Type | Chemical |
| Properties | |
| Formula | C21H20O9 |
| MW | 416.38 |
| CAS | 3681-99-0 |
| RTECS | UO5216000 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off white powder. |
| Solubility | Soluble in DMSO (10mg/ml), DMF (10mg/ml), ethanol (5mg/ml) or methanol (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HKEAFJYKMMKDOR-VPRICQMDSA-N |
| Smiles | O=C1C(C2=CC=C(O)C=C2)=COC3=C([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(O)=CC=C31 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. Daidzein and glucuronides are the main metabolites of puerarin. It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic complications, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer. The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, anti-inflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake and attenuating insulin resistance. Due to the poor water-solubility and liposolubility, the applications of puerarin are limited. Strategies to improve the bioavailability of puerarin are ongoing, various nanotechnologies and preparation technologies including microemulsions and SMEDDS, dendrimers, nanoparticles and nanocrystals have been researched to improve the bioavailability of puerarin.
Product References
(1) M.K. Choo, et al.; Biol. Pharm. Bull. 25, 1328 (2002) | (2) D.H. Overstreet, et al.; Pharm. Biochem. Beh. 75, 619 (2003) | (3) F.S. Chueh, et al.; J. Pharmacol. Sci. 96, 420 (2004) | (4) K. Nakamura, et al.; Chem. Pharm. Bull. 59, 23 (2011) | (5) S. Michihara, et al.; J. Nutr. Sci. Vitaminol. 58, 202 (2012) | (6) X.Y. Zhou, et al.; Phytother. Res. 28, 961 (2014) | (7) H.W. Jung, et al.; Nutrients 8, E33 (2017) | (8) H. Hongyun, et al.; Neurosci. Lett. 643, 45 (2017) | (9) M.Z. Int. Immunopharmacol. 61, 306 (2018) | (10) L. Zhang; Drug. Deliv. 26, 860 (2019) | (11) Y. Yi, et al.; J. Mol. Model 25, 202 (2019) | (12) D. Lian, et al.; Phytomedicine 55, 310 (2019) | (13) L. Jia, et al.; Exp. Ther. Med. 18, 543 (2019) | (14) G. Ye, et al.; Oncol. Lett. 17, 195 (2019) | (15) T. Liang, et al.; Mol. Biol. Rep. (Epub ahead of print) (2019)