Chemodex

Prostaglandin F2α tromethamine salt

Name: Prostaglandin F2α tromethamine salt
Brand: Chemodex
SKU: CDX-P0320
Price: 116.00 CHF
Availability: InStock

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CDX-P0320-M0055 mgCHF 116.00

CDX-P0320-M01010 mgCHF 142.00

CDX-P0320-M02525 mgCHF 284.00

Specifications / Handling

More Information
Product Details
Synonyms	Dinoprost trometamol; PGF2α tromethamine; Prostaglandin F2α THAM salt; Prostaglandin F2α tris salt; Lutalyse; U 14583E; NSC 196515; Minprostin F2α; Enzaprost T
Product Type	Chemical
Properties
Formula	C₂₀H₃₄O₅ . C₄H₁₁NO₃
MW	475.62
CAS	38562-01-5
Source/Host Chemicals	Synthetic
Purity Chemicals	≥99% (TLC)
Appearance	White to off-white powder.
Solubility	Soluble in DMSO, ethanol or methanol (all 50 mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	IYGXEHDCSOYNKY-RZHHZEQLSA-N
Smiles	OC(CCC/C=C\C[C@@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@@H](O)CCCCC)=O.OCC(CO)(N)CO
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	-20°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Prostaglandin F2α (PGF2α) is a widely distributed prostaglandin occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. Mechanistically, it acts via activation of the FP (prostaglandin F2α) receptor to raise intracellular calcium, driving smooth muscle contraction and facilitating luteolysis. This makes it a versatile agent both for controlled reproductive interventions and as a key tool in physiological and pharmacological research. PGF2α exhibits its receptor mediated physiological activity at 50-100nM.

Product-specific References

(1) L. Speroff & P.W. Ramwell; Am. J. Obstet. Gynecol. 107, 1111 (1970) | (2) B. Samuelsson, et al.; Annu. Rev. Biochem. 47, 997 (1978) | (3) K. Watanabe, et al.; PNAS 83, 1583 (1986) | (4) D.J. Crankshaw & V. Gaspar; J. Reprod. Fertil. 103, 55 (1995) | (5) C.W. Miller, et al.; Endocrinol. 137, 5641 (1996) | (6) F.J. Diaz, et al.; Mol. Cell Endocrinol. 191, 65 (2002) | (7) S. Basu; Med. Res. Rev. 27, 435 (2007) | (8) D. Agas, et al.; J. Cell Physiol. 228, 25 (2013) | (9) J. Kim & M. Shim; Biochim. Biophys. Acta 1853, 500 (2015) | (10) E. Goupil, et al.; J. Biol. Chem. 290, 3137 (2015)

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