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Chemodex
L-Proline
102
CHF
CHF 102.00
In stock
CDX-P0446-G100100 gCHF 102.00
CDX-P0446-K0011 kgCHF 611.00
| Product Details | |
|---|---|
| Synonyms | (S)-Pyrrolidine-2-carboxylic acid; H-Pro-OH |
| Product Type | Chemical |
| Properties | |
| Formula | C5H9NO2 |
| MW | 115.13 |
| CAS | 147-85-3 |
| RTECS | TW3584000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (50 mg/ml) or ethanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ONIBWKKTOPOVIA-BYPYZUCNSA-N |
| Smiles | O=C(O)[C@H]1NCCC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Proline is a proteinogenic amino acid that is used in the biosynthesis of proteins. L-Proline has been found to act as a weak agonist of the glycine receptor and of both NMDA and non-NMDA (AMPA/kainate) ionotropic glutamate receptors. L-proline is essential for induction of hepatocyte proliferation in culture, through its affect on synthesis of intracellular collagen. It has free radical scavenging potential. Induces differentiation of embyonic stem cells and has been studied as regulator of pluripotent cells in culture. Shows cryoprotective properties. L-Proline is used as asymmetric catalysts in organic synthesis and asymmetric aldol cyclization. It is involved in the Michael addition of dimethyl malonate to alfa-beta-unsaturated aldehydes. It finds uses in pharmaceutical, biotechnological applications due to its osmoprotectant property.
Product References
(1) A. Van Harreveld & F. Strumwasser F.; Neuroscience 6, 2495 (1981) | (2) E. Keller, et al.; J. Neurochem. 37, 1335 (1981) | (3) T. Nakamura, et al.; BBRC 122, 884 (1984) | (4) V. Henzi, et al.; Mol. Pharmacol. 41, 793 (1992) | (5) S. Usse, et al.; J. Org. Chem. 65, 914 (2000) | (6) S. Kaul, et al.; Amino Acids 34, 315 (2008) | (7) N. Verbruggen & C. Hermans; Amino Acids 35, 753 (2008) (Review) | (8) J.M. Washington, et al.; Am. J. Physiol. Cell Physiol. 298, C982 (2010) | (9) G. Zhang, et al.; Chem. Commun. 49, 7908 (2013) | (10) S. Comes, et l.; Stem Cell Reports 1, 307 (2013) | (11) H. Jin, et al.; J. Org. CHem. 81, 3263 (2016) | (12) L. Zahng, et al.; Sci. Rep. 6, 26326 (2016)