Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
Pseudolaric acid B
81
CHF
CHF 81.00
In stock
CDX-P0453-M0011 mgCHF 81.00
CDX-P0453-M01010 mgCHF 373.00
| Product Details | |
|---|---|
| Synonyms | (-)-Pseudolaric acid B; Pseudolarix acid B; PLAB; PAB; NSC 615488 |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H28O8 |
| MW | 432.46 |
| CAS | 82508-31-4 |
| RTECS | KJ4620000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (10mg/ml) or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VDGOFNMYZYBUDT-YDRCMHEVSA-N |
| Smiles | O=C(C)O[C@@]12[C@@]3(CC[C@@]2([H])[C@](C)(OC3=O)/C=C/C=C(C)/C(O)=O)CC=C(C(OC)=O)CC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Pseudolaric acid B is a natural diterpenoid isolated from the bark of Pseudolarix kaempferi. It has anti-inflammatory, anticancer, immunosuppressive, antifungal and antifertility properties. Effects relevant to its anticancer properties include, apoptosis and autophagy induction, preventing angiogenesis, microtubule-destabilizing, induction of cell cycle arrest, inhibition of multidrug resistance and inhibition of tumor growth in vivo. It inhibits NF-κ and p38 signaling and has been shown to be a PPARα signaling agonist.
Product References
(1) B.N. Zhou, et al.; Planta Med. 47, 35 (1983) | (2) E. Li, et al.; J. Nat. Prod. 58, 57 (1995) | (3) M.S. Jardat, et al.; Planta Med. 68, 667 (2002) | (4) W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004) | (5) M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004) | (6) V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005) | (7) Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006) | (8) T. Li, et al.; J. Cell Biochem. 108, 87 (2009) | (9) G. Ma, et al.; J. Cancer Res. Clin. Oncol. 136, 1333 (2010) | (10) L. Hou, et al.; J. Cancer Res. Clin. Oncol. 138, 885 (2012) | (11) N. Wei, et al: Phytother. Res. 27, 980 (2013) | (12) J. Tong, et al.; Phytother. Res. 27, 885 (2013) | (13) Q. Sun & Y. Li; PLoS One 9, e107830 (2014) | (14) M.L. Liu, et al.; Front. Pharmacol. 8, 394 (2017) (Review)