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Chemodex
Pyridoxal 5'-phosphate monohydrate
68
CHF
CHF 68.00
In stock
CDX-P0461-G0055 gCHF 68.00
CDX-P0461-G02525 gCHF 258.00
| Product Details | |
|---|---|
| Synonyms | P5P; PLP; Codecarboxylase; 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde; Pyridoxal 5-phosphate; Vitamin B6 Metabolite |
| Product Type | Chemical |
| Properties | |
| Formula |
C8H10NO6P . H2O |
| MW | 265.16 |
| CAS | 41468-25-1 |
| RTECS | UV1208000 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Slightly soluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | CEEQUQSGVRRXQI-UHFFFAOYSA-N |
| Smiles | O=C([H])C1=C(O)C(C)=NC=C1COP(O)(O)=O.[H]O[H] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The enzyme cofactor Pyridoxal-5‘-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins. It acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. It has the ability to inhibit purinergic receptors and intracellular influx of Ca2+. Pyridoxal-5‘-phosphate monohydrate can modify peptides and suppress their precursor ionization efficiency. Research shows that pyridoxal-5‘-phosphate-dependent enzymes can be inhibited by cycloserine.
Product References
(1) D.E. Kandzari, et al.; Am. J. Cardiol. 92, 660 (2003) | (2) D.W. Kim, et al.; J. Biochem. Mol. Biol. 38, 58 (2005) | (3) J.C. Tardif, et al.; J. Thorac. Cardiovasc. Surg. 133, 1604 (2007) | (4) M. Neuwirth, et al.; FEBS Lett. 583, 2179 (2009) | (5) E.S. Simon, et al.; Rapid Commun. Mass Spectrom 23, 3401 (2009) | (6) J. Lowther, et al.; Mol Biosyst. 6, 1682 (2010) | (7) J.L. Hedrick; Adv. Biochem. Psychopharmacol. 4, 23 (1972) | (8) B.I. Yang & D.E. Metzler; Methods Enzymol. 62, 528 (1979) | (9) G. Tunnicliff & T.T. Ngo; Cell Physiol. Biochem. 8, 117 (1998) | (10) P. Christen & P.K. Mehta; Chem. Rec. 1, 436 (2001) | (11) M.L. di Salvo, et al.; Front. Biosci 4, 897 (2012) | (12) L. Paul, et al.; Nutr. Rev. 71, 239 (2013)