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Chemodex
Phloretin
52
CHF
CHF 52.00
In stock
CDX-P0487-M100100 mgCHF 52.00
CDX-P0487-M250250 mgCHF 103.00
| Product Details | |
|---|---|
| Synonyms | 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone |
| Product Type | Chemical |
| Properties | |
| Formula | C15H14O5 |
| MW | 274.27 |
| CAS | 60-82-2 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO, ethanol or methanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VGEREEWJJVICBM-UHFFFAOYSA-N |
| Smiles | Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Phloretin is a natural dihydrochalcone, originally identified from the apple tree, and is a metabolite of phlorizin. It has numerous pharmacological effects, including anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and cytoprotective properties. Phloretin is a potent antioxidant, scavenging peroxynitrite (ONOO-) and/or suppressing lipid peroxidation, which contributes to the many biological properties. Phloretin has anti-aging and depigmenting effects, making it also attractive for dermatological research and application. Phloretin attacks a number of molecular targets, modulating different intracellular signaling pathways, including NF-κB, MAPK, Nrf2, and AMPK. It can modulate Ca2+ channels, PKC, GLUTs, SGLTs and other targets. The anticancer potential is based on antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities.
Product References
(1) M.R. de Oliveira; Biofactors 42, 13 (2016) (Review) | (2) B.Y. Choi; Molecules 24, 278 (2019) (Review) | (3) T.P.A. Casarini, et al.; Eur. J. Pharmacol. 889, 173593 (2020) (Review) | (4) K.T. Nakhate, et al.; Nutrients 14, 3638 (2022) (Review) | (5) H.S. Tuli, et al.; Molecules 27, 8819 (2022) (Review) | (6) S. Habtemariam;, Biomedicines 11, 143 (2023) (Review)