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Chemodex
Procyanidin B2
64
CHF
CHF 64.00
In stock
CDX-P0591-M0011 mgCHF 64.00
| Product Details | |
|---|---|
| Synonyms | (-)-Epicatechin (4β-8)-(-)-epicatechin; 4,8?-Bi-[(+)-epicatechin]; cis,cis?-4,8?-Bi-(3,3?,4?,5,7-pentahydroxy-flavan); Proanthocyanidin B2; Procyanidol B2 |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H26O12 |
| MW | 578.52 |
| CAS | 29106-49-8 |
| Source/Host Chemicals | Isolated from plant. |
| Purity Chemicals | ≥90% (HPLC) |
| Appearance | Light beige/brown to beige/brown powder. |
| Solubility | Soluble in DMSO, ethanol, DMF (all 30mg/ml) or water (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XFZJEEAOWLFHDH-NFJBMHMQSA-N |
| Smiles | O[C@@H]1[C@@H](C2=C3C(C[C@@H](O)[C@@H](C4=CC(O)=C(O)C=C4)O3)=C(O)C=C2O)C5=C(O)C=C(O)C=C5O[C@@H]1C6=CC(O)=C(O)C=C6 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Procyanidin B2, one of the most representative naturally occurring edible pigments, is usually isolated from the seeds, fruits and leaves of lots of common plants, such as grapes or apples. Procyanidin B2 has numerous bioactivities, including anti-inflammatory, anti-oxidative stress, neuroprotective, lipid metabolism regulating, wound healing, anti-diabetic, metabolic syndrome regulating, anti-atherosclerotic, anti-adipogenesis, anti-viral and anti-cancer properties. Procyanidin B2 targets and mediates several signaling pathways like NF-κB, MAPK, PI3K/Akt, NLRP3, apoptotic axis, VEGF/VEGFR2, PPARγ and Nrf-2/HO-1. Procyanidin B2 possesses the potential to treat/prevent a wide range of human diseases, such as diabetes mellitus, diabetic complications, atherosclerosis, cancers and non-alcoholic fatty liver disease.
Product References
(1) M.M. Avelar & C.M.C.P. Gouvea; Indian J. Pharm. Sci. 74, 351 (2012) | (2) H. Yang, et al.; Biochem. Pharmacol. 92, 599 (2014) | (3) T.C. Sutcliffe, et al.; Antioxidants 6, 77 (2017) | (4) S. Gopalakrishnan, et al.; IUBMB Life 70, 445 (2018) | (5) J. Feng, et al.; J. Cell. Mol. Med. 23, 6479 (2019) | (6) Y. Tian, et al.; Front. Immunol. 10, 1895 (2019) | (7) X. Zhu, et al.; Antioxid. Redox Signal. 35, 75 (2021) | (8) L. Liu, et al.; Pharmacol. Res. 177, 106127 (2022) | (9) M. Xu, et al.; Anim. Biotechnol. 33, 346 (2022) | (10) Q. Sun, et al.; Bioengineered 13, 6500 (2022) | (11) J. Liu, et al.; Nutrients 14, 1756 (2022) | (12) J. Zhao, et al.; Cell Death Dis. 13, 594 (2022) | (13) H. Wang, et al.; Int. J. Mol. Sci. 23, 7769 (2022) | (14) W. Cai, et al.; Int. Immunopharmacol. 113, 109336 (2022) | (15) Y.P. Zou, et al.; J. Orthop. Res. 41, 1555 (2023) | J. Chen, et al.; Food Chem. 420, 136101 (2023)