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Chemodex
Pioglitazone hydrochloride
As low as
58
CHF
CHF 58.00
In stock
Only %1 left
CDX-P0733-M01010 mgCHF 58.00
CDX-P0733-M05050 mgCHF 232.00
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| Product Details | |
|---|---|
| Synonyms | 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride; U 72107A |
| Product Type | Chemical |
| Properties | |
| Formula | C19H20N2O3S . HCl |
| MW | 392.9 |
| CAS | 112529-15-4 |
| RTECS | XJ5813440 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or DMF (both 10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | GHUUBYQTCDQWRA-UHFFFAOYSA-N |
| Smiles | CCC(C=C1)=CN=C1CCOC2=CC=C(CC3SC(NC3=O)=O)C=C2.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Pioglitazone hydrochloride is a proliferator-activated receptor γ (PPARγ) agonist (EC50 = ~500-600nM for both human and murine PPARγ) and thiazolidinedione (TZD) anti-diabetic. Pioglitazone is a selective agonist of the nuclear receptor peroxisome proliferator-activated receptor γ (PPAR-γ) and to a lesser extent PPAR-α. Pioglitazone hydrochloride is usually used to treat type-II diabetes in vivo and has the ability to block hepatic gluconeogenesis. Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM. In vivo, pioglitazone (0.3-3mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats. It shos also anti-inflammatory and anti-arteriosclerosis effects.
Product References
(1) Y. Sugiyama, et al.; Arzneimittelforschung 40, 263 (1990) | (2) J.M. Lehmann, et al.; J. Biol. Chem. 270, 12953 (1995) | (3) T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996) | (4) J. Sakamoto, et al.; BBRC 278, 704 (2000) | (5) T.M. Willson, et al.; J. Med. Chem. 43, 527 (2000) | (6) M. Ishibashi, et al.; Hypertension 40, 687 (2002) | (7) P. de Pablos-Velasco; Expert Rev. Cardiovasc. Ther. 8, 1057 (2010) | (8) C. Ao, et al.; Cell Biol. Int. 34, 723 (2010) | (9) H.L. Zhang, et al.; Neuroscience 176, 381 (2011) | (10) Q. Zhao, et al.; J. Neuroinflamm. 13, 259 (2016) | (11) S. Suzuki, et al.; Int. J. Mol. Sci. 17, E2071 (2016) | (12) C.E. Shannon, et al.; FEBS J. 284, 451 (2017)