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Chemodex
Quinidine (anhydrous)
64
CHF
CHF 64.00
In stock
CDX-Q0029-G01010 gCHF 64.00
CDX-Q0029-G05050 gCHF 258.00
| Product Details | |
|---|---|
| Synonyms | α-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H24N2O2 |
| MW | 324.42 |
| CAS | 56-54-2 |
| RTECS | VA4725000 |
| Source/Host Chemicals | Isolated from plant. |
| Purity Chemicals | ≥99% (Titr.) |
| Appearance | White to faint yellow powder. |
| Solubility | Soluble in DMSO (20mg/ml) or ethanol (5mg/ml). |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | LOUPRKONTZGTKE-LHHVKLHASA-N |
| Smiles | O[C@@H](C1=C(C=C(OC)C=C2)C2=NC=C1)[C@]3([H])[N@](C[C@@H]4C=C)CC[C@@]4([H])C3 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Quinidine is a dextrorotatory stereoisomer of Quinine with anti-malarial, anti-arrhythmic (class 1A), anti-inflammatory, anti-cancer and anti-viral properties. Quinidine acts as a blocker of voltage-gated sodium channels. Inhibition of the Nav1.5 channel is specifically involved in its anti-arrhythmic effects as a class I anti-arrhythmic agent. Quinidine also blocks certain voltage-gated potassium channels (e.g., Kv1.4, Kv4.2, hERG, among others), acts as an anti-muscarinic. Quinidine blocks α1-adrenoceptors (alpha1ARs) and is an inhibitor of cytochrome P450 and acetylcholinesterase.
Product References
(1) N.J. White, et al.; Lancet 2, 1069 (1981) | (2) K. Schenck-Gustafsson, et al.; Am. J. Cardiol. 51, 777 (1983) | (3) L. Crevasse; Am. J. Cardiol. 62, 22I (1988) | (4) A Yatani, et al.; Circ. Res. 73, 351 (1993) | (5) J.A. Yao, et al.; J. Pharmacol. Exp. Ther. 279, 856 (1996) | (6) K. Shibata, et al.; Circulation 97, 1227 (1998) | (7) S. Wang, et al.; J. Physiol. 546, 387 (2003) | (8) J.M. Hutzler, et al.; Chem. Res. Toxicol. 16, 450 (2003) | (9) L.A. McLaughlin, et al.; J. Biol. Chem. 280, 38617 (2005) | (10) M.K. Pugsley, et al.; Clin. Exp. Pharmacol. Physiol. 32, 60 (2005) | (11) B. Bozic, et al.; Mini Rev. Med. Chem. 18, 468 (2018) | (12) L. Vitali Serdoz, et al.; Pharmacol. Res. 144, 257 (2019) | (13) Z. Che, et al.; Chem. Biodivers. 17, e1900696 (2020) | (14) Z. Li, et al.; Angew. Chem. Int. Ed. Engl. 60, 11474 (2021)