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Chemodex
Resorufin pentyl ether
142
CHF
CHF 142.00
In stock
CDX-R0015-M0011 mgCHF 142.00
CDX-R0015-M0055 mgCHF 483.00
| Product Details | |
|---|---|
| Synonyms | Pentoxyresorufin; 7-Pentoxyresorufin; O7-Pentylresorufin |
| Product Type | Chemical |
| Properties | |
| Formula | C17H17NO3 |
| MW | 283.32 |
| CAS | 87687-03-4 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | Orange to red powder. |
| Solubility | Soluble in acetonitrile, DMSO or ethanol (all ~1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ZPSOKQFFOYYPKC-UHFFFAOYSA-N |
| Smiles | O=C1C=C2OC3=CC(OCCCCC)=CC=C3N=C2C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Resorufin pentyl ether (7-Pentoxyresorufin) is a fluorogenic substrate used for monitoring cytochrome P450 (CYP450) activities in cell extracts and solutions. It is used as substrate for 7-Pentoxyresorufin-O-dealkylase (PROD) assays. It is used to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Cytochrome P450 oxidase is a large number of evolutionary related oxidative enzymes important in animal, plant, and bacterial physiology. Most cytochromes P450 (CYPs) have about 500 amino acids and a heme group at the active site. Upon enzymatic cleavage of 7-Pentoxyresorufin by CYP450, the fluorescent hydrolysis product resorufin is released and its fluorescence can be used to quantify enzyme activity. Spectral data of Resorufin: λex=571nm, λem=585nm. Resorufin pentyl ether shows also antibacterial properties.
Product References
(1) R.A. Lubet, et al.; Arch. Biochem. Biophys. 238, 43 (1985) | (2) D. Parma, et al.; Mol. Cell Biochem. 189, 201 (1998) | (3) S. Uehara, et al.; J. Pharmacol. Exp. Ther. 339, 651 (2011) | (4) M.V. Caballero, et al.; Food Chem. Toxicol. 83, 215 (2015) | (5) D.M. Schmitt, et al.; Int. J. Antimircob. Agents 48, 367 (2016) | (6) H. Ozaki, et al.; J. Toxicol. Sci. 41, 551 (2016) | (7) R.O. Juvonen, et al.; ACS Omega 6, 11286 (2021) | (8) S. Uehara, et al.; Drug Metab. Pharmacokinet. 44, 100454 (2022)