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Chemodex
Rebaudioside A
41
CHF
CHF 41.00
In stock
CDX-R0090-G0055 gCHF 41.00
CDX-R0090-G02525 gCHF 162.00
CDX-R0090-G05050 gCHF 244.00
| Product Details | |
|---|---|
| Synonyms | Glycoside A3; Glycoside X; Stevioside A3; Reb A |
| Product Type | Chemical |
| Properties | |
| Formula |
C44H70O23 |
| MW | 967.01 |
| CAS | 58543-16-1 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in water (10mg/ml) or DMSO. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HELXLJCILKEWJH-NCGAPWICSA-N |
| Smiles | C=C1[C@@]2(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@H](O)[C@@H](CO)O3)C[C@]6(C1)CC[C@]7([H])[C@](C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)CCC[C@@]7(C)[C@]6([H])CC2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a α-glucosidase inhibitor with (IC50=35μg/ml) and can inhibit ATP-sensitive K+-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine model. Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent.
Product References
(1) R. Abudula, et al.; Metab.53, 1378 (2004) | (2) R. Abudula, et al.; Diabetes Obes. Metab. 10, 1074 (2008) | (3) D.J. Brusick; Food Chem. Toxicol. 46, S83 (2008) | (4) M. Upreti, et al.; Molecules 17, 4186 (2012) | (5) D. Ripken, et al.; J. Agric. Food Chem. 62, 8365 (2014) | (6) N. van der Wielen, et al.; J. Nutr. 146, 2429 (2016) | (7) D.H. Shin, et al.; Diabetes Metab. J. 40, 283 (2016) | (8) B.R. Adari, et al.; Food Chem. 200, 154 (2016) | (9) Y. Wang, et al.; Eur. J. Pharmacol. 822, 128 (2018)