Chemodex

Rebaudioside A

CHF 41.00
In stock
CDX-R0090-G0055 gCHF 41.00
CDX-R0090-G02525 gCHF 162.00
CDX-R0090-G05050 gCHF 244.00
More Information
Product Details
Synonyms Glycoside A3; Glycoside X; Stevioside A3; Reb A
Product Type Chemical
Properties
Formula

C44H70O23

MW 967.01
CAS 58543-16-1
Source/Host Chemicals Plant
Purity Chemicals ≥98% (HPLC)
Appearance White powder.
Solubility Soluble in water (10mg/ml) or DMSO.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key HELXLJCILKEWJH-NCGAPWICSA-N
Smiles C=C1[C@@]2(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@H](O)[C@@H](CO)O3)C[C@]6(C1)CC[C@]7([H])[C@](C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)CCC[C@@]7(C)[C@]6([H])CC2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +20°C
Long Term Storage +20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at RT.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a α-glucosidase inhibitor with (IC50=35μg/ml) and can inhibit ATP-sensitive K+-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine model. Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent.

Product References

(1) R. Abudula, et al.; Metab.53, 1378 (2004) | (2) R. Abudula, et al.; Diabetes Obes. Metab. 10, 1074 (2008) | (3) D.J. Brusick; Food Chem. Toxicol. 46, S83 (2008) | (4) M. Upreti, et al.; Molecules 17, 4186 (2012) | (5) D. Ripken, et al.; J. Agric. Food Chem. 62, 8365 (2014) | (6) N. van der Wielen, et al.; J. Nutr. 146, 2429 (2016) | (7) D.H. Shin, et al.; Diabetes Metab. J. 40, 283 (2016) | (8) B.R. Adari, et al.; Food Chem. 200, 154 (2016) | (9) Y. Wang, et al.; Eur. J. Pharmacol. 822, 128 (2018)

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.