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Chemodex
Rutin
108
CHF
CHF 108.00
In stock
CDX-R0400-M05050 mgCHF 108.00
| Product Details | |
|---|---|
| Synonyms | Rutoside; Phytomelin; Sophorin; Birutan; Eldrin; Birutan Forte; Rutin trihydrate; Globularicitrin; Violaquercitrin; Quercetin rutinoside |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H30O16 |
| MW | 610.52 |
| CAS | 153-18-4 |
| RTECS | VM2975000 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Pale yellow powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | IKGXIBQEEMLURG-NVPNHPEKSA-N |
| Smiles | O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.
Product References
(1) I.B. Afanas'ev, et al.; Biochem. Pharmacol. 38, 1763 (1989) | (2) R.P. Webster, et al.; Cancer Lett. 109, 185 (1996) | (3) E.A. Ostrakhovitch & I.B. Afanas'ev; Biochem. Pharmacol. 62, 743 (2001) | (4) N. Kamalakkannan & P.S. Prince; Basic Clin. Pharmacol. Toxicol. 98, 97 (2006) | (5) J.P. Lin, et al.; Leuk. Res. 33, 823 (2009) | (6) R. Lapa Fda, et al.; J. Pharm. Pharmacol. 63, 875 (2011) | (7) S.W. Wang, et al.; Neurotoxicology 33, 482 (2012) | (8) X. Yuan, et al.; FASEB J. 31, 333 (2016)