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Chemodex
Sertraline hydrochloride
68
CHF
CHF 68.00
In stock
CDX-S0088-M01010 mgCHF 68.00
CDX-S0088-M05050 mgCHF 272.00
| Product Details | |
|---|---|
| Synonyms | (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride; CP 51,974-1; Lustral; Seserine; Zoloft |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H17NCl2 . HCl |
| MW | 342.69 |
| CAS | 79559-97-0 |
| RTECS | QJ0352070 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (20mg/ml) or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | BLFQGGGGFNSJKA-XHXSRVRCSA-N |
| Smiles | ClC(C=C1)=C(Cl)C=C1[C@H]2C3=C(C=CC=C3)[C@@H]([NH2+]C)CC2.[Cl-] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Sertraline is a tetraline that inhibits monoamine transporters and acts as a potent highly selective serotonin reuptake inhibitor (SSRI), with affinity for the serotonin transporter (SERT), increasing availability of serotonin (5-hydroxytryptamine; 5-HT) in the brain and leading to antidepressant, anxiolytic and antiobsessional effects. Sertraline binds also to the dopamine transporter (DAT) and the σ1 receptor (but not the σ2 receptor) with 100-fold lower affinity. It acts as an antagonist of the σ1 receptor, and is able to reverse σ1 receptor-dependent actions of fluvoxamine, a potent agonist of the receptor, in vitro. Sertraline displays antiproliferative activity on human colorectal carcinoma cells.
Product References
(1) B.K. Koe, et al.; J. Pharmacol. Exp. Ther. 226, 686 (1983) | (2) W.M. Welch, et al.; J. Med. Chem. 27, 1508 (1984) | (3) J. Heym & B.K. Koe; J. Clin. Psychiatry 49, 40 (1988) | (4) M. Tatsumi, et al.; Eur. J. Pharmacol. 340, 249 (1997) | (5) G. MacQueen, et al.; CNS Drug Reviews 7, 1 (2001) | (6) H.R. Khouzam, et al.; Compr. Ther. 29, 47 (2003) | (7) J.H. Meyer, et al.; Am. J. Psych. 161, 826 (2004) | (8) B. Lowe, et al.; J. Affect. Disord. 87, 271 (2005) | (9) Y. Albayrak & K. Hashimoto; Adv. Exp. Med. Biol. 964, 153 (2017)