Sodium salicylate

Sodium salicylate is a metabolite of aspirin. It is a cell-permeable, non-steroidal anti-inflammatory agent (NSAID) that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. It selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases and TNF-induced activation of JNK. It induces apoptosis via p38 kinase activation and inhibits COX-2 and inducible NOS (iNOS) transcription dependent on the experimental setup. It is commonly used for its antipyretic, anti-oxidant, neuroprotective, anti-inflammatory, anti-cancer and analgesic properties.