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Chemodex
Silibinin
As low as
75
CHF
CHF 75.00
In stock
Only %1 left
CDX-S0276-G01010 gCHF 75.00
CDX-S0276-G100100 gCHF 597.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | 2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin; Silybin; NSC 651520; Flavobin; Silymarin I |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H22O10 |
| MW | 482.44 |
| CAS | 22888-70-6 |
| RTECS | DJ2981770 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to slightly yellow powder. |
| Solubility | Soluble in DMSO (10mg/ml) or DMF (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | SEBFKMXJBCUCAI-PQVVKJAFSA-N |
| Smiles | OC1=C2C(O[C@@H](C3=CC=C(O[C@@H](CO)[C@H](C4=CC=C(O)C(OC)=C4)O5)C5=C3)[C@H](O)C2=O)=CC(O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
Silibinin is a naturally occurring flavanone from Silybum marianum (milk thistle plant) and the main component (active principle) of the Silymarin extract. Silibinin has shown pleiotropic biological properties, including potent antioxidant, anti-inflammatory, anticancer, antidiabetic, hepatoprotective, neuroprotective, antiviral, antimicrobial and immunosuppressive activities. Silibinin demonstrates promising anticancer effects in vitro and in vivo. The molecular mechanisms of silibinin-mediated antiproliferative effects are mainly via receptor tyrosine kinases, androgen receptor, STATs, NF-κB, cell cycle arrest and apoptotis/autophagy inducing signaling pathways in various cancer cells. Silibinin was reported to improve glycemic homeostasis by improving the activity of pancreatic β-cells, increasing insulin sensitivity of liver and muscle cells and decreasing lipid deposition in adipocytes. Next to modulating the NFκ signaling pathway, Sibilin also inhibits NLRP1/NLRP3 inflammasomes signaling pathways. It modulates many molecular changes caused by xenobiotics and ultraviolet radiation to protect the skin and is used in cosmeceutical preparations.
Product-specific References
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