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Chemodex
Triptolide
102
CHF
CHF 102.00
In stock
CDX-T0237-M0011 mgCHF 102.00
CDX-T0237-M0055 mgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | PG 490; NSC163062; TPL |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H24O6 |
| MW | 360.40 |
| CAS | 38748-32-2 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | DFBIRQPKNDILPW-KTGKZQHOSA-N |
| Smiles | O=C(OC1)C2=C1C(C[C@H](O3)[C@]43[C@@]56[C@@H](O6)[C@H]7[C@@](O7)(C(C)C)[C@H]4O)[C@]5(C)CC2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Interferes with a number of transcription factors including p53, NF-κB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity.
Product References
(1) S.M. Kupchan, et al.; JACS 94, 7194 (1972) | (2) Y. Yang, et al.; Immunopharmacology 40, 139 (1998) | (3) H. Liu, et al.; Acta Pharmacol. Sin. 21, 782 (2000) | (4) B.J. Chen; Leuk. Lymphoma 42, 253 (2001) (Review) | (5) S. Yang, et al.; Mol. Cancer Ther. 2, 65 (2003) | (6) S.M. Johnson, et al.; J. Surg. Res. 168, 197 (2011) | (7) J. Pan; Cancer Lett. 292, 149 (2010) (Review) | (8) N. Mujumdar, et al.; Gastroenterol. 139, 598 (2010) | (9) D.V. Titov, et al.; Nat. Chem. Biol. 7, 182 (2011) | (10) J. Zhang, et al.; Arzneimittelforschung 61, 727 (2011) | (11) Y. Lu, et al.; Chem. Biol. 21, 246 (2014)
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