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Chemodex
Telmisartan
34
CHF
CHF 34.00
In stock
CDX-T0460-M01010 mgCHF 34.00
CDX-T0460-M05050 mgCHF 102.00
| Product Details | |
|---|---|
| Synonyms | BIBR 277; Micardis; Pritor; 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid |
| Product Type | Chemical |
| Properties | |
| Formula | C33H30N4O2 |
| MW | 514.62 |
| CAS | 144701-48-4 |
| RTECS | DV2037500 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, chloroform, DMF or ethanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | RMMXLENWKUUMAY-UHFFFAOYSA-N |
| Smiles | CN1C2=CC=CC=C2N=C1C3=CC(N(CC4=CC=C(C5=CC=CC=C5C(O)=O)C=C4)C(CCC)=N6)=C6C(C)=C3 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively inhibits the angiotensin II AT1 receptor subtype (Ki=3.7nM). Telmisartan exhibits antihypertensive activity in a renin-dependent model of hypertension. In addition to blocking the renin-angiotensin system (RAS), telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-γ), a central regulator of insulin and glucose metabolism and improving insulin sensitivity. It is believed that telmisartan's dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk and glomerulosclerosis. Furthermore, telmisartan inhibits proliferation in several cancer models by inducing apoptosis and cell cycle arrest.
Product References
(1) U.J. Ries, et al.; J. Med. Chem. 36, 4040 (1993) | (2) W. Wienen, et al.; Br. J. Pharmacol. 110, 245 (1993) | (3) K.J. McClellan & A. Markham; Drugs 56, 1039 (1998) | (4) S.C. Benson, et al.; Hypertension 43, 993 (2004) | (5) X. Rong, et al.; J. Pharmacol. Exp. Ther. 331, 1096 (2009) | (6) R.E. Schmieder, et al.; J. Nephrol. 24, 263 (2011) | (7) J.E. Frampton; Drugs 71, 651 (2011) (Review) | (8) T. Kozako, et al.; FEBS Open Bio 6, 442 (2016) | (9) E. Samukawa, et al.; Int. J. Oncol. 51, 1674 (2017)
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