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Chemodex
Trazodone hydrochloride
As low as
45
CHF
CHF 45.00
In stock
Only %1 left
CDX-T0476-G0011 gCHF 45.00
CDX-T0476-G0055 gCHF 103.00
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| Product Details | |
|---|---|
| Synonyms | 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride; AF 1161; Desyrel; Molipaxin; KB 831; Pragmazone; Thombran; Trazolan; Tombran; Trittico; Bimaran; Mesyrel |
| Product Type | Chemical |
| Properties | |
| Formula | C19H22ClN5O . HCl |
| MW | 408.32 |
| CAS | 25332-39-2 |
| RTECS | XZ5660000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (10mg/ml), methanol (10mg/ml) or water (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | OHHDIOKRWWOXMT-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC(N(CC2)CCN2CCCN3N=C(C=CC=C4)N4C3=O)=C1.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Trazodone hydrochloride belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). Trazodone hydrochloride has anti-depressant and neuroprotectant activity. Trazodone hydrochloride exerts antagonistic properties against α1- and α2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects. Shown to enhance neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Its broad pharmacological activity makes it a valuable tool in both neuroscience research and therapeutic development. Can be used as a reference compound.
Product References
(1) A. Georgotas, et al.; Pharmacotherapy 2, 255 (1982) | (2) S.G. Bryant & L. Ereshefsky; Clin. Pharm. 1, 406 (1982) | (3) A. Fagiolini, et al.; Review CNS Drugs 26, 1033 (2012) | (4) M. Halliday, et al.; Brain 140, 1768 (2017) | (5) V. Bortolotto, et al.; ACS Chem. Neurosci. 8, 2027 (2017)