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Chemodex
(Bis(trifluoroacetoxy)iodo)benzene
As low as
64
CHF
CHF 64.00
In stock
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CDX-T0620-G01010 gCHF 64.00
CDX-T0620-G05050 gCHF 155.00
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| Product Details | |
|---|---|
| Synonyms | BTIB; PIFA; Phenyliodine bis(trifluoroacetate) |
| Product Type | Chemical |
| Properties | |
| Formula | C10H5F6IO4 |
| MW | 430.04 |
| CAS | 2712-78-9 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95% (AT) |
| Appearance | Colorless to white powder or crystals. |
| Solubility | Soluble in chloroform. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PEZNEXFPRSOYPL-UHFFFAOYSA-N |
| Smiles | O=C(C(F)(F)F)OI(OC(C(F)(F)F)=O)C1=CC=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
(Bis(trifluoroacetoxy)iodo)benzene (BTIB; PIFA) is a hypervalent iodine reagent widely used as a mild and selective oxidizing agent in organic synthesis. It facilitates oxidative transformations such as phenol coupling, dearomatization, α-oxygenation of carbonyl compounds, and heterocycle formation under mild conditions, often avoiding harsh metal-based oxidants. (Bis(trifluoroacetoxy)iodo)benzene is also employed in peptide and carbohydrate chemistry for oxidative cleavage and functionalization of sensitive substrates.
Product References
(1) P.V. Pallai, et al.; Int. J. Pept. Protein Res. 21, 84 (1983) | (2) P.V. Pallai, et al.; Biochemistry 24, 1933 (1985) | (3) M. Catir, et al.; J. Org. Chem. 74, 4560 (2009) | (4) D. Kumar, et al.; Bioorg. Med. Chem. Lett. 19, 4492 (2009) | (5) N. Chatterjee, et al.; Org. Biomol. Chem. 13, 4828 (2015) | (6) T. Imai, et al.; J. Org. Chem. 81, 3975 (2016) | (7) Y. Wan, et al.; J. Org. Chem. 84, 780 (2019) | (8) C. Mudithanapelli, et al.; Org. Lett. 21, 3098 (2019) | (9) C. Mudithanapelli & M.H. Kim; Org. Biomol. Chem. 18, 450 (2020) | (10) X.T. Sun, et al.; Molecules 27, 726 (2022) | (11) Y. Matsuo, et al.; Angew. Chem. Int. Ed. Engl. 62, e202314968 (2023)