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Chemodex
Umbelliferon
54
CHF
CHF 54.00
In stock
CDX-U0001-G02525 gCHF 54.00
CDX-U0001-G100100 gCHF 122.00
| Product Details | |
|---|---|
| Synonyms | 7-Hydroxycoumarin; 7-Hydroxy-2H-1-benzopyran-2-one; NSC 19790 |
| Product Type | Chemical |
| Properties | |
| Formula |
C9H6O3 |
| MW | 162.14 |
| CAS | 93-35-6 |
| RTECS | GN6820000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Beige solid. |
| Solubility | Soluble in DMSO (10mg/ml), ethanol (5 mg/ml), methanol (5 mg/ml) or dioxane. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ORHBXUUXSCNDEV-UHFFFAOYSA-N |
| Smiles | O=C1OC2=CC(O)=CC=C2C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Umbelliferone is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor, antioxidant, antihyperglycemic, anti-inflammatory, neuroprotective and antidepressant-like properties. It inhibits the growth of a variety of human cell lines. It increases the production of reactive oxygen species (ROS), depolarizes the mitochondrial membrane, and halts the cell cycle at the G0/G1 phase in KB human oral carcinoma cells. Umbelliferone has been used as a ratiometric pH indicator. Spectral Data: Em=460nm / Ex=330(ph<6)/370nm(pH>8). Umbelliferone can also be used as building block to synthesize fluorescent probes or biochemically active APIs.
Product References
(1) D.W. Fink & W.R. Koehler; Anal. Chem. 42, 990 (1970) | (2) M.E. Marshall, et al.; J. Cancer Res. Clin. Oncol. 120, S3 (1994) | (3) B. Ramesh & K.V. Pugalendi; J. Med. Food 9, 562 (2006) | (4) K.S. Lee, et al.; Org. Lett. 10, 49 (2008) | (5) K. Iliopoulos, et al.; JACS 132, 14343 (2010) | (6) S.R. Subramaniam & E.M. Ellis; J. Neurosci. Res. 91, 453 (2013) | (7) A. Rauf, et al.; Nat. Prod. Res. 28, 1371 (2014) | (8) T. Qin, et al.; Behav. Brain Res. 317, 147 (2017) | (9) A. Vijayalakshmi & G. Sindhu; Biomed. Pharmacother. 92, 661 (2017) | (10) X. Wang, et al.; Acta Pharm. 69, 111 (2019)