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Chemodex
Vinblastine sulfate
143
CHF
CHF 143.00
In stock
CDX-V0013-M02525 mgCHF 143.00
CDX-V0013-M05050 mgCHF 353.00
| Product Details | |
|---|---|
| Synonyms | VLB; Vincaleukoblastine sulfate salt; NSC 49842 |
| Product Type | Chemical |
| Properties | |
| Formula |
C46H58N4O9 . H2SO4 |
| MW | 909.05 |
| CAS | 143-67-9 |
| RTECS | YY8400000 |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to light yellow powder. |
| Solubility | Soluble in DMSO (10mg/ml), DMF (10mg/ml) or water (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | KDQAABAKXDWYSZ-JKDPCDLQSA-N |
| Smiles | O=S(O)(O)=O.O[C@@]1(C(OC)=O)[C@]2([H])N(C)C3=C(C=C([C@@](C(OC)=O)(C[C@@H](C[C@]4(CC)O)C[N@@](C4)CC5)C6=C5C(C=CC=C7)=C7N6)C(OC)=C3)[C@]28[C@@]([C@](C=CC9)(CC)[C@H]1OC(C)=O)([H])N9CC8 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Vinblastine sulfate is a vinca alkaloid and a chemical analog of vincristine. It is an anticancer agent with anti-mitotic properties and immunosuppressive activity. Vinblastine sulfate depolymerizes microtubules by binding tubulin and inducing self-association in spiral aggregates. This reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Vinblastine sulfate has been observed to arrest the cell cycle in the G2/M-phase by blocking mitotic spindle formation. Vinblastine sulfate has also been documented to trigger Raf-1 activation and phosphorylation of Bcl-2 family proteins, to induce p53 expression, and to induce apoptosis in several tumor cell lines. Shown to inhibit autophagosome maturation.
Product References
(1) M.A. Jordan, et al.; Cancer Res. 45, 2741 (1985) | (2) R.H. Himes; Pharmacol. Ther. 51, 257 (1991) | (3) K. Tsukidate, et al.; Am. J. Pathol. 143, 918 (1993) | (4) D. Panda, et al.; J. Biol. Chem. 271, 29807 (1996) | (5) S.S. Rai & J. Wolf; J. Biol. Chem. 273, 31131 (1998) | (6) E. Tashiro, et al.; Jpn. J. Cancer Res. 89, 940 (1998) | (7) A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) | (8) M.A. Jordan & L. Wilson; Meth. Enzymol. 298, 252 (1998) | (9) S.S. Rai, et al.; PNAS 95, 4253 (1998) | (10) G.K. Chen, et al.; Br. J. Cancer. 83, 892 (2000) | (11) R.A. Veldhoen, et al.; Oncogene 32, 736 (2012) | (12) P. Keglevich, et al.; Molecules 17, 5893 (2012) (Review)