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Chemodex
Zinquin ethyl ester
81
CHF
CHF 81.00
In stock
CDX-Z0013-M0011 mgCHF 81.00
CDX-Z0013-M0055 mgCHF 204.00
CDX-Z0013-M05050 mgCHF 1'083.00
| Product Details | |
|---|---|
| Synonyms | 2-[[2-Methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-acetic acid ethyl ester |
| Product Type | Chemical |
| Properties | |
| Formula | C21H22N2O5S |
| MW | 414.47 |
| CAS | 181530-09-6 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO. Slightly soluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | KCASTCXJTDRDFT-UHFFFAOYSA-N |
| Smiles | CCOC(=O)COC1=CC(NS(=O)(=O)C2=CC=C(C)C=C2)=C2N=C(C)C=CC2=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Zinquin ethyl ester is a cell-permeable, lipophilic, zinc-sensitive, fluorescent derivative of Zinquin. Cleavage of the ethyl ester group via cytosolic esterases in living cells impedes its efflux across the plasma membrane. It is selective for Zn (II) in the presence of physiological concentrations of Ca (II) and Mg (II) ions. Fluorescence of Zinquin ethyl ester is enhanced upon binding Zn (II), but the probe does not demonstrate a shift or change in emission wavelength. The probe is UV-excitable and emits in the blue region of the spectrum. Ex(max) 368nm, Em(max) 490nm. Zinquin ethyl ester has been used to monitor intracellular zinc fluxes associated with apoptosis.
Product References
(1) I.B. Mahadevan et al.; Australian Journal of Chemistry 49(5), 561-568 (1996) | (2) J.C. Fahrni & T.V. O'Halloran; JACS 121(49), 11448-11458 (1999) | (3) A.Q. Truong-Tran, et al.; The Journal of Nutrition 130, 1459 (2000) | (3) D. Lu, et al.; Adv. Mater. 31, e1902739 (2019)
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