Zincon monosodium salt

CHF 51.00
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CDX-Z0028-G0011 gCHF 51.00
CDX-Z0028-G0055 gCHF 115.00
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Product Details
Synonyms 2-[5-(2-Hydroxy-5-sulfophenyl)-3-phenyl-1-formazyl]benzoic acid monosodium salt; 2-Carboxy-2'-hydroxy-5'-sulfoformazyl-benzene monosodium salt
Product Type Chemical
Properties
Formula C20H15N4NaO6S
MW 462.41
CAS 62625-22-3
Source/Host Chemicals Synthetic.
Purity Chemicals ~85%
Appearance Dark violet powder.
Solubility Slightly soluble in water (20°C), alcohol or aqueous alkali. Insoluble in most organic solvents.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key DVHNWVSFUULGKM-SWJPHGMYSA-M
Smiles O=S(C1=CC=C(O)C(/N=N/C(C2=CC=CC=C2)=N/NC3=CC=CC=C3C(O)=O)=C1)([O-])=O.[Na+]
Shipping and Handling
Shipping AMBIENT
Short Term Storage +20°C
Long Term Storage +20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +20°C.
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Product Specification Sheet
Datasheet Download PDF

A colorimetric reagent for Zn, Cu and Hg detection and a metal indicator in EDTA titration. The aqueous solution of Zincon is yellow or orange-yellow in weak alkaline conditions, and turns blue in the presence of Cu (maximum wavelength: 600nm, molar absorptivity: 1.9x104) and Zn (pH 8.5-9.5, maximum wavelength: 620nm, molar absorptivity: 23,000). Used for the spectrophotometric determination of zinc, simultaneous determination of zinc and copper and for automated flow injection spectrometric determination of zinc. Binds nonspecifically proteins at acidic pH and was therefore used to stain proteins fast and background-free in sodium dodecyl sulfate polyacrylamide gel (SDS-Page). Sligthly less sensitivity than Coomassie Brilliant Blue®CBB but stains and destains more rapidly. Additionally, zincon staining is reversible, suggesting it might be applicable to 2-D PAGE and downstream analyses by mass spectrometry. Shown to inhibit insulin binding to its receptor and to attenuate the activity of ATPase and other enzymes, presumably because of the chelating properties of the dye.

Product References

(1) G.K. Singhal & K.N. Tandon; Talanta 14, 1351 (1967) | (2) K. Vytras, et al.; Talanta 22, 529 (1975) | (3) F. Mollinedo, et al.; Eur J Biochem. 119, 183 (1981) | (4) H. Ono & A. Ito; J. Biochem. 95, 345 (1984) | (5) M.A. Koupparis, et al.; The Analyst 111, 1311 (1986) | (6) C.M. Corns; Ann. Clin. Biochem. 24, 591 (1987) | (7) J.I. Monreal, et al.; Rev. Esp. Fisiol. 43, 133 (1987) | (8) E. Hilario, et al.; J. Biochem. Biophys. Methods 21, 197 (1990) | (9) R.M. Liu, et al.; Talanta 40, 511 (1993) | (10) J.K. Choi, et al.; Electrophoresis 23, 4053 (2002) | (11) G.B. Smejkal & H.F. Hoff; Biotechn. 34, 486 (2003) | (12) C.E. Saebel, et al.; Anal. Biochem. 397, 218 (2010)

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