CX3CL1 (human):Fc (human) (rec.)

CHF 170.00
In stock
CHI-HF-210CX3C-C02525 µgCHF 170.00
CHI-HF-210CX3C-C100100 µgCHF 450.00
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Product Details
Synonyms Fractalkine; Chemokine (C-X3-C Motif) Ligand 1; Neurotactin; SCYD1
Product Type Protein
Properties
Source/Host CHO cells
Sequence

The extracellular domain of human CX3CL1 (aa 25-100) is fused to the N-terminus of the Fc region of human IgG1.

Crossreactivity Human
Purity ≥98% (SDS-PAGE)
Endotoxin Content <0.06EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute at 100μg/ml in sterile PBS.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

NCBI reference AAH01163.1: CX3CL1 (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

CX3CL1 [Fractalkine] is expressed on TNF-α and IL-1 activated endothelial cells (ECs) and binds to CX3CR1. CX3CL1 can exist in 2 forms, as membrane-anchored or as a shed 95-kDa glycoprotein. The soluble CX3CL1 has potent chemoattractant activity for T cells and monocytes, and the cell surface bound protein, which is induced on activated primary endothelial cells, promotes strong adhesion of those leukocytes. CX3CL1 may play a role in regulating leukocyte adhesion and migration processes at the endothelium.

Product References
  1. Role of Fractalkine in promoting inflammation in sepsis-induced multiple organ dysfunction: X. Chen, et al.; Inf. Gen. Evol. 85, 104569 (2020)
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