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Chimerigen
IL-8 (human) (rec.) (His)
190
CHF
CHF 190.00
In stock
CHI-HR-20008-C01010 µgCHF 190.00
CHI-HR-20008-C05050 µgCHF 560.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-8; CXCL8; C-X-C Motif Chemokine 8; Emoctakin; GCP-1; LAI; MDNCF; MONAP; NAP-1; NCF; TCF |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human IL-8 (aa 28-99) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| Purity | ≥97% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg protein (LAL test; Lonza). |
| Reconstitution | Reconstituted in sterile H2O not less than 100μg/ml, which can then be further diluted in other aqueous solutions. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
| Other Product Data | NCBI reference NP_000575.1: IL-8 (human) |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the α (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumor cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro.
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