CD27 (human) (rec.) (His)

CHF 380.00
In stock
CHI-HR-200CD27-C05050 µgCHF 380.00
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Product Details
Synonyms T Cell Activation Antigen CD27; T14; TNFRSF7; Tumor Necrosis Factor Receptor Superfamily Member 7; S152
Product Type Protein
Source/Host E. coli
Sequence Human CD27 (aa 21-192) is fused at the C-terminus to a His-tag.
Crossreactivity Human
Purity ≥97% (SDS-PAGE)
Endotoxin Content <0.1EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute in sterile water not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Formulation Lyophilized from 0.2μm-filtered solution in 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.
Other Product Data NCBI reference AAH12160.1: CD27 (human)
Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-κB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.

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