eTOPIX_PARylation & PARPs - Important Posttranslation Modification in Cellular Stress Response – Sent on 22 February 2021

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eTOPIX Product Highlights - 22 February 2021 | www.adipogen.com

PARylation & PARPs
Importance for Cellular Physiology and Stress Response

Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation (PAR), a fundamental posttranslational modification of proteins, using NAD+ as substrate.
There are 18 PARP family members including PARP-1 being one of the most important PARPs.
PAR regulates genome integrity, but is also involved in cell death or survival, inflammation activation and stress response.

The STANDARD BULK Sizes Available!anti-Poly(ADP-ribose) [PAR], mAb (Clone 10H)

AdipoGen Life Sciences' anti-Poly(ADP-ribose) [PAR], mAb (10H) (Prod. No. AG-20T-0001) is considered to be the standard antibody in the field of PARylation, published in hundreds of publications. This antibody has been used in Western blot, IHC, ICC and flow cytometry studies. The monoclonal antibody 10H recognizes poly(ADP-ribose) synthesized by a broad range of PARPs (poly(ADP-ribose) polymerases). 10H binds to PAR chains >10 ADP-ribose units in length and allows to visualize PAR formation at the level of intact cells.

This useful antibody is now available in a convenient 1mg catalog size.

Figure: Typical western blot pattern using anti-PAR (10H). Dose-dependence of H2O2 induced PARylation (PARP-1 activation) in U937 cells, as detected at 10min with a threshold of PARP-1 activation at 200mM. Control lanes show unchanged protein levels of PARP-1 and PKA under the same experimental conditions (A. Brunyanszki, et al.; Mol. Pharmacol. 86, 450 (2014)).

Highly Active PARP & PARG Enzymes!

PARP-1 [ARTD1] (catalytic domain) (human) (rec.) (His)

AG-40T-0010

PARP-1 [ARTD1] (human) (rec.) (His) (high purity)

AG-40T-0011

PARP-2 [ARTD2] (mouse) (rec.) (His) (high purity)

AG-40T-0012

PARP-3 [ARTD3] (human) (rec.) (His) (high purity)

AG-40T-0013

UNIQUE PARG (human) (rec.) (His) (highly active)

AG-40T-0022

Other Unique Antibodies for Detection of
Posttranslation Modifications!

anti-Polyglutamylation Modification, mAb (GT335)

AG-20B-0020

anti-Polyglutamate chain (polyE), pAb (IN105)

AG-25B-0030

anti-α-Tubulin (acetylated), mAb (TEU318)

AG-20B-0068

anti-Tubulin (glycylated), pAb (Gly-pep1)

AG-25B-0034

Download
the Tubulin Code Product Flyer

Tubulins and microtubules (MTs) are major substrates for Posttranslational modifications (PTMs). They include tyrosination/detyrosination, D2-tubulin formation, acetylation, phosphorylation, polyamination, ubiquitination, polyglutamylation and glycylation. All are important for wound healing, neurogenesis, immune response and cancer research.

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