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eTOPIX_RevMab Rabbit Recombinant Monoclonal Antibodies for Improved Results – Sent on 14 January 2021
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| eTOPIX Product Highlights - 14 January 2021 | www.adipogen.com | ||||||||||||||||||
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 UNIQUE Rabbit Recombinant Antibodies for IMPROVED Research Results |
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RevMAb rabbit monoclonal antibodies are developed from a broad range of antigen-specific B cells that are inaccessible to traditional hybridoma technology. After extensive screening and clone selection, RevMAb antibodies are purified and recombinantly produced from an animal origin-free source. The portfolio of RevMAb includes sensitive primary rabbit monoclonal antibodies specific for mutations, histone-modifications, histone-mutants, DNA methylations, epitope tags or PEG, always aiming to produce high quality diagnostic research tools. In addition, they also provide unique consistent and reliable secondary goat monoclonal antibodies.  Androgen Receptor (AR) is a phosphoprotein that regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Mutations in the AR signaling pathway have been linked to a number of diseases. The ARv7 splice variant is frequently expressed in castration-resistant prostate cancer (CRPC). RevMAb's recombinant rabbit monoclonal clone RM7 (#REV-31-1109-00) detects specifically the human androgen receptor splice variant 7 (AR-V7) and does not cross-react with wild-type AR. Figure: Immunohistochemical staining of formalin-fixed and paraffin-embedded bone metastasis prostate cancer tissue using anti-AR (ARv7 var) (human), Rabbit Monoclonal (RM7). Tissues are clinically validated to be negative for ARv7 (back) and positive for ARv7 (front).  Other Mutation-specific Antibodies!
 Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Histone H3 is one of the DNA-binding proteins. Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation has long been implicated in cancers. Recently, recurrent histone mutations (including H3K4M, H3K9M, H3K27M, H3K36M, and H3G34V/R/W) have been identified in multiple cancers and have been shown to impede histone methylation. RevMAb's recombinant rabbit monoclonal clone RM263 (#REV-31-1145-00) detects specifically the human histone H3.3 G34W mutant and does not cross-react with wild-type histone H3.3. Figure: Immunohistochemical staining of formalin-fixed and paraffin-embedded 293T cells transfected with a DNA constract encoding Histone H3.3 G34W mutant (left) or H3.3 wiltype (right) using anti-Histone H3.3 G34W (human), Rabbit MAb (RM263). Other Histone Mutation-specific Antibodies!
  5-Methylcytosine is one of the best known epigenetic modifications. It is a methylated form of the DNA base cytosine that regulates gene transcription and is involved in epigenetics. 5-Methylcytosine is a very important repressor of transcription in the genome. When present in promoters, 5-methylcytosine is associated with stable, long-term transcriptional silencing. RevMAb's recombinant rabbit monoclonal clone RM231 (#REV-31-1110-00) detects specifically 5-methylcytosine in both single-stranded and double-stranded DNA. Does not cross-react with non-methylated cytosine and hydroxy-methylcytosine in DNA. Figure: Immunocytochemical staining of HeLa cells using anti-5-Methylcytosine, Rabbit Monoclonal (RM231) (red). Actin filaments have been labeled with fluorescein phalloidin (green) and nuclei are stained with DAPI (blue). Other DNA Methylation-specific Antibodies!
 The covalent attachment of PEG (PEGylation) is commonly used to modify a variety of proteins and drugs. Some of the therapeutical benefits of PEGylated molecules include increased bioavailability, increased blood circulation of the drug, optimized pharmacokinetics, decreased immunogenicity and decreased frequency of administration. RevMAb's recombinant rabbit monoclonal clone RM105 (#REV-31-1008-00) detects the methoxy-group of Polyethylene glycol (PEG). It is specific for methoxypoly(ethylene glycol). Figure: Immunohistochemical staining of mouse liver and kidney using anti-Polyethylene Glycol (methoxy group), Rabbit Monoclonal (RM105). The mouse was injected with PEG-BSA or BSA for 3 hours before sampling. Also Available:
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