RevMab

anti-BAG-1 (human), Rabbit Monoclonal (RM356)

CHF 459.00
In stock
REV-31-1242-00-R100100 µlCHF 459.00
More Information
Product Details
Synonyms Bcl-2-associated Athanogene 1; BAG Family Molecular Chaperone Regulator 1
Product Type Recombinant Antibody
Properties
Clone RM356
Isotype Rabbit IgG
Source/Host Rabbit
Immunogen/Antigen A peptide corresponding to human BAG-1 (Bcl-2-associated athanogene 1).
Application

Immunohistochemistry (IHC): 1:500-1:1000 dilution
Western Blot (WB): 1:1000-1:2000 dilution

Crossreactivity Human
Specificity

This antibody reacts to total human BAG-1 protein, including long (BAG-1L), medium (BAG-1M) and short (BAG-1S) isoforms.

Purity Protein A purified.
Purity Detail Protein A affinity purified from an animal origin-free culture supernatant.
Concentration N/A
Formulation Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control

Rabbit IgG

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number Q99933
Declaration Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

BAG-1 belongs to a family of evolutionary conserved proteins, containing an approximately 110 amino acid sequence termed the BAG domain that defines the protein family. BAG1 was identified in a screen of interacting proteins of the anti-apoptotic protein BCL2. BAG1 shares no significant homology with BCL2 or other BCL2 family proteins, which can form homo- and heterodimers. However, coexpression of BAG1 and BCL2 provided markedly increased protection from cell death induced by several stimuli. BAG1 itself is made up of different isoforms translated from a single mRNA by alternative translational initiation, resulting in similar carboxy-terminal sequences but different N-terminal sequences. In humans, there are four BAG1 isoforms (BAG1L, 1M, 1 and 1S). The multiple protein isoforms interact with diverse partners, including chaperones Hsc70/Hsp70, Ser/Thr kinase Raf-1 and Bcl-2, to promote cancer cell survival. The BAG-1L isoform specifically binds to and increases the transcriptional activity of oestrogen receptor in cells, and in some, but not all studies, BAG-1 expression is predictive of clinical outcome in breast cancer.

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