RevMab

anti-MSH6 (human), Rabbit Monoclonal (RM376)

CHF 459.00
In stock
REV-31-1262-00-R100100 µlCHF 459.00
More Information
Product Details
Synonyms DNA Mismatch Repair Protein Msh6; GTBP GTMBP; p160
Product Type Recombinant Antibody
Properties
Clone RM376
Isotype Rabbit IgG
Source/Host Rabbit
Immunogen/Antigen A mammalian cells expressed recombinant protein fragment of human Msh6.
Application

Immunohistochemistry (IHC): 1:100-1:500 dilution
Western Blot (WB): 1:1000-1:2000 dilution

Crossreactivity Human
Specificity

This antibody reacts to human DNA mismatch repair protein Msh6.

Purity Protein A purified.
Purity Detail Protein A affinity purified from an animal origin-free culture supernatant.
Concentration N/A
Formulation Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control

Rabbit IgG

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number P52701
Declaration Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

The mismatch repair (MMR) proteins are required to maintain genomic integrity in prokaryotes and eukaryotes, by correcting single mismatches and short unpaired regions, such as small insertions and deletions. In eukaryotes, three proteins are involved in mismatch recognition, MSH2, MSH3 and MSH6. The three proteins form two heterodimers MutSalpha (MSH2-MSH6) and MutSbeta (MSH2-MSH3). MutSalpha is thought to be involved primarily in the recognition and repair of base-base mismatches and small insertion/deletion loops. MutSbeta acts preferentially on insertion/deletion loops up to 12 nucleotides in length. The MSH2, MSH3, and PMS2 mismatch repair proteins are also involved in other DNA repair pathways such as single-strand annealing and homologous recombination, anti-recombination, DNA damage signaling, apoptosis, as well as site-specific mutagenesis during immunoglobin somatic hypermutation and class switch recombination. They interact with several other oncogenic targets, including ATR, BRCA1 or p53. Deficiencies in expression of DNA repair genes underlie many forms of cancer. If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage may increase mutations due to error-prone translesion synthesis and error prone repair. Elevated DNA damage may also increase epigenetic alterations due to errors during DNA repair. Such mutations and epigenetic alterations may give rise to cancer. MSH6 mutation is a commonly associated with hereditary nonpolyposis colorectal cancer (HNPCC). MSH6 mutations have also been linked to endometrial cancer and the development of endometrial carcinomas.

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