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RevMab
anti-IDH1 (R132H) (human), Rabbit Monoclonal (RM390)
459
CHF
CHF 459.00
In stock
REV-31-1276-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human glioblastoma using Anti-IDH1(R132H) Rabbit Monoclonal Antibody (Clone RM390) at a 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Isocitrate Dehydrogenase 1; Oxalosuccinate Decarboxylase |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM390 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to human (R132H mutant specific). |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human IDH1(R132H). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | O75874 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumors, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma.