anti-Foxp1 (human), Rabbit Monoclonal (RM402)

Foxp1 (Forkhead box P1) belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. The Foxp1 protein contains both DNA-binding- and protein-protein binding-domains. This protein may act as a tumor suppressor as it is lost in several tumor types. Foxp1 regulates a variety of important aspects of development including tissue development of the lungs, brain, thymus and heart. In the heart Foxp1 has 3 vital roles, these include the regulation of cardiac myocyte maturation and proliferation, outflow tract separation of the pulmonary artery and aorta and expression of Sox4 in cushions and myocardium. Foxp1 is also an important regulator of lung airway morphogenesis. Foxp1 knockout embryos display severe defects in cardiac morphogenesis. Disruptions of FoxP1 have been identified in very rare human patients and lead to cognitive dysfunction, including intellectual disability and autism spectrum disorder, together with language impairment.