anti-CD14 (human), Rabbit Monoclonal (RM415)

CD14 is a GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages and neutrophils and which is part of the innate immune system as a pattern recognition receptor. CD14 serves as a multifunctional lipopolysaccharide receptor together with TLR-4 and MD-2) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and croup.