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RevMab
anti-RNASEH2B (human), Rabbit Monoclonal (RM433)
459
CHF
CHF 459.00
In stock
REV-31-1321-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human colon cancer tissue sections using anti-RNASEH2B antibody (RM433) at 1:100 dilution.
Figure 2: Immunohistochemical staining of formalin fixed and paraffin embedded human lung cancer tissue sections using anti-RNASEH2B antibody (RM433) at 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | RNase H2 Subunit B; Ribonuclease H2 Subunit B; Aicardi-Goutieres Syndrome 2 Protein; AGS2; Deleted in Lymphocytic Leukemia 8 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM433 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human RNASEH2B. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution Western Blot (WB): 1:1000-1:2000 dilution |
| Crossreactivity | Human |
| Specificity |
RM433 reacts to human RNASEH2B. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q5TBB1 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection.