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RevMab
anti-Stat6, Rabbit Monoclonal (RM473)
459
CHF
CHF 459.00
In stock
REV-31-1365-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human solitary fibrous tumor tissue sections using Anti-Stat6 antibody (RM473) at 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Signal Transducer and Activator of Transcription 6 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM473 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues near the C-terminus of human Stat6. |
| Application |
IHC: 1:100 - 1:200 WB: 1:1000 - 1:2500 |
| Crossreactivity | Human |
| Specificity |
RM473 reacts to human Stat6. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P42226 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
STAT6 (Signal transducer and activator of transcription 6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. STAT6 is activated by the binding of interleukin-4 (IL-4) to its receptor. IL-4 is a cytokine that is produced by T cells, B cells, and mast cells. When IL-4 binds to its receptor, it triggers a series of events that lead to the phosphorylation of STAT6. Phosphorylated STAT6 then dimerizes and translocates to the nucleus, where it binds to DNA and activates the transcription of a number of genes. The genes that are activated by STAT6 play a role in a number of different biological processes, including Th2 cell differentiation, IgE production, eosinophil differentiation, mast cell activation and is involved in the development of some types of cancer.
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