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RevMab
anti-TIA1 (human), Rabbit Monoclonal (RM490)
459
CHF
CHF 459.00
In stock
REV-31-1382-00-R100100 µlCHF 459.00
Figure 1: Western Blot of Jurkat cell lysate using anti-TIA1 rabbit monoclonal antibody (RM490) at 1:1000 dilution.
| Product Details | |
|---|---|
| Synonyms | T-cell-restricted Intracellular Antigen-1; Cytotoxic Granule Associated RNA-binding Protein TIA1 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM490 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human TIA1. |
| Application |
Western Blot (WB): 1:1000-1:2000 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human TIA-1. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P31483 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
TIA1, also named as p40-TIA-1, is involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). It possesses nucleolytic activity against cytotoxic lymphocyte target cells. TIA1 may be involved in apoptosis. Similar to the ALS-related disease proteins TDP-43, hnRNPA1, and FUS, TIA1 is an RNA-binding protein containing a prionlike LCD and assembles into membrane-less organelles, including SGs. TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition. In live cells,TIA1 mutations delayed stress granule (SG) disassembly and promoted the accumulation of non-dynamic SGs that harbored TDP-43.