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RevMab
anti-Acetylated-Lysine, Rabbit Monoclonal (RM101)
518
CHF
CHF 518.00
In stock
REV-32-1012-00-C100100 µgCHF 518.00
Figure 1: Immunocytochemical staining of HeLa cells using Anti-Acetylated Lysine antibody (RM101) (red). Actin filaments was labeled with fluorescein phalloidin (green)
| Product Details | |
|---|---|
| Synonyms | Kac; AcK |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM101 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | Acetyllysine -BSA. |
| Application |
Western Blot (WB): 1:500 -1:2000 dilution |
| Crossreactivity | All |
| Specificity |
This antibody reacts to lysine-acetylated proteins. No cross reactivity with nonacetylated lysine, and lysine with other modification. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | 1 mg/ml |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | N/A |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Acetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. Post-translational acetylation occurs on the epsilon amino group of lysine residues as a reversible and highly dynamic post-translational modification (PTM) that is known to be a key regulator in multiple cellular events, including chromatin structure, transcription, metabolism, signal transduction and cytoskeletal regulation. The acetylation of lysine residues in proteins is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines.