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AdipoGen Life Sciences
AG-CN2-0321
CHF 0.00
Out of stock
| Product Details | |
|---|---|
| Synonyms | NCI 145-635; 3-Formylrifamycin; 3-Formylrifampicin SV; 3-Formylrifamycin SV; Rifaldehyde |
| Product Type | Chemical |
| Properties | |
| Formula |
C38H47NO13 |
| MW | 725.8 |
| CAS | 13292-22-3 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow-orange powder. |
| Solubility | Soluble in DMSO, aqueous MeCN or EtOH. |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
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Ansamycin antibiotic.
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Intermediate of rifampicin.
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Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
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Effective against mycobacteria, and are therefore used in research of tuberculosis, leprosy and mycobacterium avium complex (MAC) infections.
Product References
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Rifamycins: A General View: S. Riva & L.G. Silvestri; Ann. Rev. Microbiol. 26, 199 (1972)
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Spin-labeled rifamycin: biological activity: Z.Z. Raykov, et al.; Pharmazie 63, 61 (2008)
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New anti-tuberculosis agents amongst known drugs: K.A.E. Lougheed, et al.; Tuberculosis 89, 364 (2009)
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The effect of complexation of 3-formylrifamycin SV macrocyclic ether derivatives with metal cations and small nitrogen-containing organic molecules on antibacterial activity against S. aureus and S. epidermidis: P. Przybylski, et al.; Bioorg. Med. Chem. Lett. 25, 3903 (2015)
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Rifamycin antibiotics - new compounds and synthetic methods. Part 4: Study of the reaction of 3-formylrifamycin SV with secondary amines and ketones: K. Bujnowski, et al.; Tetrahedr. 71, 158 (2015)