UcH-L3 (human) (rec.) (untagged)

CHF 155.00
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SBB-DE0023-C05050 µgCHF 155.00
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Product Details
Synonyms Ubiquitin C-terminal Hydrolase L3; Ubiquitin Thioesterase L3
Product Type Protein
Properties
Source/Host E. coli
Sequence Human UcH-L3 (aa 1-230) (Accession Nr. P15374) is untagged.
Crossreactivity Human
Application Typical working concentration range is 0.5-5nM.
MW ~26kDa
Purity ≥95% (SDS-PAGE)
Concentration Lot dependent.
Accession Number P15374
Formulation Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.
Other Product Data Click here for a Typical Lot-specific Product Datasheet from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by South Bay Bio.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -80°C
Long Term Storage -80°C
Handling Advice Aliquot to avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

UCHL3 (Ubiquitin C-terminal Hydrolase L3) is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. It plays a role in regulating apical membrane recycling and indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response in retinal, skeletal muscle and germ cell maintenance. UCHL3 is also known to hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. It digests precursors and ubiquitinated proteins to generate monomeric ubiquitin.

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