AG13958

CHF 299.00
In stock
SYN-1004-M0011 mgCHF 299.00
SYN-1004-M0055 mgCHF 593.00
SYN-1004-M01010 mgCHF 910.00
SYN-1004-M05050 mgCHF 1'903.00
SYN-1004-M100100 mgCHF 3'280.00
 
More Information
Product Details
Synonyms AG-13958
Product Type Chemical
Properties
Formula C26H22FN7O
MW 467.5
CAS 319460-94-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: VEGF | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key LLMBCXVXEQNNJB-DHZHZOJOSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
AG13958 is a VEGF inhibitor that was in clinical development for treatment of age-related macular degeneration (AMD). The drug displays low water solubility and so far in trials delivery has been difficult needing direct injection to be truly effective and it varied by the species used because of species specific differences in eye circulation and vascularization. As a VEGF inhibitor AG13958 was targeted to FLT/TYK receptor inhibition.
Product References
  1. 2nd Ophthalmic Drug Development and Delivery Summit: M. Marra, et al.; Expert Opin. Drug Deliv. 4, 77 (2007)
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