BMS-5

CHF 96.00
In stock
SYN-1024-M0011 mgCHF 96.00
SYN-1024-M0055 mgCHF 144.00
SYN-1024-M01010 mgCHF 215.00
SYN-1024-M05050 mgCHF 658.00
SYN-1024-M100100 mgCHF 1'137.00
 
More Information
Product Details
Synonyms BMS5
Product Type Chemical
Properties
Formula C17H14Cl2F2N4OS
MW 431.3
CAS 1338247-35-0
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: LIMK1 - LIMK2 | Kinase Group: TKL | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key IVUGBSGLHRJSSP-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has been found to limit migration of human fibrosarcoma cells. Thus, the inhibition of LIMK1 and/or LIMK2 enzymes have been suggested as targets for treating cancer, including reduction or prevention of metastasis. BMS-5 is a potent inhibitor of the LIM kinase. It has IC(50) values of 7nM and 8nM for LIMK1 and LIMK2 respectively. LIMK1/2 activity was measured via TCA precipitation assay using a biotinylated ADF (actin depolymization factor) as the protein substrate and the kinase domains of LIMK1 and LIMK2 as the enzyme sources in the presence of 1µM ATP.
Product References
  1. Phenyl-substituted pyrimidine compounds useful as kinase inhibitors: S.T. Wrobelski, et al.; WO2006084017 (2006)
  2. Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton: E. Mashiach-Farkash, et al.; Oncotarget 3, 629 (2012)
  3. LIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis: S. Ray, et al.; Mol. Biol. Cell 25, 2393 (2014)
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