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SynKinase
BX-795
CHF 0.00
In stock
SYN-1026-M0011 mgCHF 92.00
SYN-1026-M0055 mgCHF 142.00
SYN-1026-M01010 mgCHF 192.00
SYN-1026-M05050 mgCHF 766.00
SYN-1026-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | BX795 |
| Product Type | Chemical |
| Properties | |
| Formula | C23H26IN7O2S |
| MW | 591.5 |
| CAS | 702675-74-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PDK1 | Kinase Group: AGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | VAVXGGRQQJZYBL-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC(50) 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-ε. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC(50) values ranging from submicromolar amounts (0.368µM to greater than 450µM.
Product References
- Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1: R.I. Feldmann, et al.; J. Biol. Chem. 280, 19867 (2005)
- The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007)
- Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation: K. Clark, J. Biol. Chem. 284, 14136 (2009)
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