IC87114

CHF 72.00
In stock
SYN-1045-M0011 mgCHF 72.00
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More Information
Product Details
Synonyms IC-87114
Product Type Chemical
Properties
Formula C22H19N7O
MW 397.4
CAS 371242-69-2
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI3K | Kinase Group: Lipid Kinase | Substrate: Lipid

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key GNWHRHGTIBRNSM-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kδ. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not adhesion as well as cellular polarization. More recent work has shown the PIK3δ inhibition also plays a role in autoimmune disease suppression.
Product References
  1. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement: C. Sadhu, et al.; J. Immunol. 170, 2647 (2003)
  2. The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors: A. Berndt, et al.; Nat. Chem. Biol. 6, 117 (2010)
  3. PI3Kdelta and PI3Kgamma as targets for autoimmune and inflammatory diseases: T.D. Cushing, et al.; J. Med. Chem. 55, 8559 (2012)
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