SynKinase

IC87114

Name: IC87114
Brand: SynKinase
SKU: SYN-1045
Price: 85.00 CHF
Availability: InStock

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Specifications / Handling

More Information
Product Details
Synonyms	IC-87114
Product Type	Chemical
Properties
Formula	C₂₂H₁₉N₇O
MW	397.4
CAS	371242-69-2
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: PI3K \| Kinase Group: Lipid Kinase \| Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	GNWHRHGTIBRNSM-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kδ. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not adhesion as well as cellular polarization. More recent work has shown the PIK3δ inhibition also plays a role in autoimmune disease suppression.

Product-specific References

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement: C. Sadhu, et al.; J. Immunol. 170, 2647 (2003)
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors: A. Berndt, et al.; Nat. Chem. Biol. 6, 117 (2010)
PI3Kdelta and PI3Kgamma as targets for autoimmune and inflammatory diseases: T.D. Cushing, et al.; J. Med. Chem. 55, 8559 (2012)

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